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- Our review focused on microenvironment and its role in mediating acquired drug resistance. 本文就肿瘤微环境及其在介导获得性耐药和凋亡抵抗中的作用作-综述。
- Endostatin, a 20 kD C-terminal fragment of collagen XVIII, is a potent inhibitor of angiogenesis and tumor growth without acquired drug resistance in animal models. Endostatin (血管内皮抑素) 是一个20 kDa 的蛋白质,能有效阻止肿瘤血管生成,动物模型试验也表明endostatin能有效地抑制小鼠多种移植肿瘤生长,且无任何毒性。
- The total drug resistance rate was 30.6%,the initial and the acquired drug resistance rate was 26.6% and 52.3% respectively,and the multi-drug resistance rate was 7.6%. 总耐药率为30.;6%25;初始耐药率为26
- This example prompts, at least in some patients with acquired drug resistance can be overcome, not all tumor cells would have been used for some kind of drug resistance. 这个例子提示,至少在部分患者身上获得性的耐药是可以被克服的,并非所有的肿瘤细胞都会一直对某种用过的药物耐药。
- Therefore, to improve the efficacy of cancer chemotherapy, seeking and identifying the mechanisms of acquired drug resistance become a hotspot in current researches. 因此,为了提高肿瘤化疗的效果,寻找和辨识肿瘤获得性耐药机制已成为当今研究的热点。
- Control and therapy of Enterococcus in clinic become more and more difficult because it has special mechanisms of acquired drug resistance and some virulence factors. 由于肠球菌携带多种毒力因子和具有多重耐药性、天然耐药性以及获得性耐药等特性,给临床肠球菌感染的治疗和控制带来了极大的困难。
- Many researches have suggested that tumor microenvironment plays an important role in mediating acquired drug resistance and confers resistance to physiologic mediators of cell death. 目前,大量研究认为肿瘤微环境在介导肿瘤获得性耐药和抵抗细胞死亡的生理性调节中发挥了重要作用。
- Methods In two ovarian carcinoma cell lines-one (COC 1) sensitive to cisplatin and one (COC 1/DDP) with acquired drug resistance, the cell growth inhibition rate, apoptotic rate and cell cycle were measured. 方法 以人卵巢癌亲代细胞株COC1 及其耐药亚株 COC1 /DDP为材料 ,计算细胞生长抑制率、细胞凋亡率及进行细胞周期分析。
- The specific niches within it may provide a sanctuary for subpopulations tumor cells that affords a survival advantage following initial drug exposure and may promote acquired drug resistance. 肿瘤微环境中特殊的生态位可能为肿瘤细胞亚群提供了一个“避难所”,即在最初暴露于化疗药物之后提供了一种生存优势,它促进了肿瘤获得性耐药的发生。
- Acquired drug resistant tuberculosis 结核,获得性耐药
- Study on socio-behavioral risk factors of acquired drug resistance of tuberculosis in Sichuan province 四川省获得性耐药结核病患者社会行为危险因素的研究
- Kirby-Bauer was used to detect the drug resistance. 采用kirby -Bauer法检测其耐药性。
- acquired drug resistance 获得性耐药
- K562/ADM had no drug resistance to As2O3 and matrine. 非细胞毒性剂量的三氧化二砷和苦参碱均可部分逆转有多药耐药表型的细胞株K562/ADM对阿霉素的耐药J险,二者联合应用效果优于单独应用,具有协同作用。
- Such misuse of medicines can lead to drug resistance. 这样滥用药物会导致抗药性。
- To develop effective combination of drug resistance modulators. 目的:寻找有效的多药耐药联合逆转剂。
- The mechanism by which pancreatic cancer cells acquire drug resistance against 5-FU and gemcitabine 胰腺癌细胞对5氟脲嘧啶和健择的获得性耐药机制的研究
- Objective To study the acquired infection rate, pathogens, drug sensitivity and drug resistance of patients in an encephalo thoracic surgical ICU in hospital. 目的研究脑胸外科ICU内患者的获得性感染的发生率、致病菌、药敏与耐药情况。
- Drug resistance surveillance of pulmonary tuberculosis in Jiaxing City. 嘉兴市肺结核病耐药监测。
- Study on infections and drug resistance of mycoplasma in female vaginalis. 株解脲支原体耐药分析。