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- Pm Dr. Jiong Wu, Cell Signaling Technology Phospho-Tyrosine Kinase Specific Antibodies: From Targets to Therapeutics. 磷酸化酪氨酸激酶特异性抗体:从靶标到治疗的发展。
- Abstract Abstract In recent years, small G proteins have become an intensively studied group of regulatory GTP hydrolyses involved in cell signaling. 摘要 近年来,小G蛋白的调控途径已经成为人们研究细胞信号转导过程的热点问题。
- This process is used in a wide range of biochemical reactions, including allergic responses and cell signaling in cancer. 该处理为生物化学反应宽广领域中采用,包括过敏反应和癌症中细胞信号传导等。
- Protein nitration will induce the changes of protein catalytic activities, cell signaling and cell skeletal structure,and lead to relevant pathological events. 蛋白质硝化将会直接影响蛋白质的催化活性、细胞信号传递和细胞骨架结构,导致相关病症的发生发展。
- He did his postdoctoral training on apoptosis at the Weizmann Institute of Sciences in Israel, and on cancer cell signaling at the Harvard Medical School in the United States. 1997年赴以色列魏兹曼研究所接受博士后训练,从事细胞凋亡或程序性细胞死亡的研究;2000年进入美国哈佛大学医学院继续博士后研究工作,主要研究领域为肿瘤细胞信号传导。
- ABSTRACT In the quantities of regulation mechanisms of cell signaling transduction, the phosphorylation and dephosphorylation of proteins are of importance. 中文摘要 在细胞信号转导的众多调节过程中,蛋白质的磷酸化与去磷酸化是十分重要的环节,特定细胞蛋白质酪氨酸残基发生磷酸化是细胞信号转导的重要调节机制,它是细胞间通信、细胞生长和增殖、细胞周期调控、分化、恶性肿瘤的发生和转移、神经传导、血管形成、胚胎形成和许多遗传病及后天人类疾病的一个关键步骤。
- Protein nitration will induce the changes of protein catalytic activities, cell signaling and cell skeletal structure, and lead to relevant pathological events. 蛋白质硝化将会直接影响蛋白质的催化活性、细胞信号传递和细胞骨架结构,导致相关病症的发生发展。
- Cell signal transduction is major research field in life science,and 10 Nobel Prizes in medicine and physiology were awarded in this field. 细胞信号转导是目前生命科学研究的一个重要内容,至今已获得10次诺贝尔生理与医学奖,说明了它的重要性。
- PIP_2 is a pivotal regulator in cell signaling pathway. DAG and IP_3, which are generated from PIP_2 hydrolysis by PLC, act as second messengers to activate PKC and induce intracellular Ca release, respectively. PIP_2是细胞信号转导通路中的关键调节因子,经磷脂酶C(PLC)水解后可生成DAG及IP_3,二者可作为第二信使,分别激活PKC与促使细胞内钙库释钙。
- Tyrosine protein kinase is one of the key kinases in cell signal transduction,which plays an important role in cell growth,development and functional regulation. 酪氨酸蛋白激酶是细胞信号转导的主要信号酶之一,对细胞的生长、发育与功能调控起着重要的作用。
- This paper reviews the close connection of senescence and pertinent pathological changes with cell signal transductions which have brought obstacles or abnormity. 概述了衰老及相关病变与细胞信号转导障碍或异常的密切关系。
- Cell signaling Cells communicate with one another in multicellular organisms using extracellular signaling molecules or hormones . 细胞信号转导 在多细胞生物中,细胞用胞外信号分子或激素彼此进行交流。
- Experimental studies have showed its effects in inhibiting metastases,apoptotic induction,cell signal transduction and prevention of liver carcinogenesis. 实验研究发现其具有抗转移、诱导肿瘤细胞凋亡、影响细胞信号转导以及预防肝癌发生的作用。
- While ACTM gene is well known to code a-actinin 1 protein which involes in cell skeleten and cell signals. ACTN1编码辅肌动蛋白1,则是公认的与细胞骨架和细胞通讯有关的基因。
- Receptor tyrosine protein kinase is one of key kinases in cell signal transduction and plays an important role in the process of cell growth, development and functions regulated by growth factors. 受体酪氨酸蛋白激酶是细胞信号转导进行的关键信号酶,在生长因子调控细胞生长、发育与功能的过程中起着重要的生理作用。
- Two important cell signal pathways, JAK-STAT pathway and MAPK pathway, transfer the signals between regulators and hematopoietic relative genes. 两条主要的细胞信号转导通路,JAK-STAT通路和MAPK通路,介导调节调节因子对造血相关基因的活性调控。
- Wireless signal field test aimed at measuring and evaluating indoor cell signal distribution system, an outdoor macrocell signal interference with other systems in the indoor signal distribution. 无线信号场强测试的目的在于测量和评估室内分布系统各小区信号、室外宏蜂窝信号、其他系统干扰信号在室内分布的情况。
- Its anti tumor effect exhibits cell proliferation suppression, appoptosis induction, cell signal disturbing, tumor suppression gene activity enhancing and oncogene expression suppression etc. 其抗肿瘤作用主要表现在抗细胞增殖、诱导细胞凋亡、干预细胞信号转导和增强抑癌基因活性及抑制癌基因表达等功效。
- ROS induce programmed cell death or necrosis, induce or suppress the expression of many genes, and activate cell signalling cascades, such as those involving. 活性氧可以诱导细胞程序性死亡或坏死、可以诱导或抑制许多基因的表达,也可以激活上述级联信号。
- With the mechnism of IPF were studies, antioxidate, anticytokine, and the inhibition of cell signals conduction have gived choices of the treatment of IPF. 随着对IPF发病机制研究的深入,抗氧化治疗,抗细胞因子治疗及阻止细胞内信号传导已成为肺纤维化治疗的方向。