PIP_2 is a pivotal regulator in cell signaling pathway. DAG and IP_3, which are generated from PIP_2 hydrolysis by PLC, act as second messengers to activate PKC and induce intracellular Ca release, respectively.

• PIP_2是细胞信号转导通路中的关键调节因子，经磷脂酶C(PLC)水解后可生成DAG及IP_3，二者可作为第二信使，分别激活PKC与促使细胞内钙库释钙。