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- Voltage gated sodium channels (VGSC) are responsible for the rising phase of the action potential in the membrane of neurons and most electrically excitable cells. 电压门控钠通道(VGSC)在神经元及大多可兴奋性细胞动作电位的形成和传播过程中扮演着极为重要的角色。
- The voltage gated sodium channel is the major target receptor for DDT and pyrethroids, and is the basis of their cross resistance (knockdown resistance). 电压门控的钠通道是拟除虫菊酯 (Pyrethroid)和滴滴涕 (dichloro diphenyl trichloroethane)的共同靶变点 ,是它们产生交互抗性 (击倒抗性 ,Knockdownresistance)的基础。
- Keywords neurotoxin;voltage gated sodium channel;allosteric modulation;receptor binding site; 神经毒素;电压门控钠通道;变构调制;受体靶点;
- Keywords Compound Erjingling polysaccharide;voltage gated sodium channel;Hippocampal neuron; 复方二精灵;海马神经元;电压门控性钠通道;
- voltage gated sodium channel 海马神经元
- Hyperexcitability of neurons plays a critical role in the generation of neuropathic pain, and appears to be intimately linked to the plasticity of voltage - gated sodium channel subunits. 大量研究表明,神经元的异常兴奋是神经性疼痛产生的主要原因之一,并且这种异常兴奋与钠离子通道亚单位的可塑性有关。
- Under whole-cell patch-clamp recording, sodium current (INa) was activated when the voltage was around -60 mV, and the peak current occurred at about +10 mV. 在全细胞电压钳条件下,神经细胞Na+通道电流(INa)在-60mV左右激活,+10mV左右达峰值,对河豚毒素敏感。
- Voltage gated Na + channel(VGSC)is the target of numerous natural neurotoxins. 电压门控钠通道(VGSC)是许多天然生物神经毒素特异作用的靶受体。
- The ranolazine works by blocking what is called delayed inward sodium current. 雷诺嗪的作用机制是阻断迟发性钠离子内流。
- Rasmusson RL, Morales MJ, Wang S, et al. Inactivation of voltage gated cardiac K+ channels[J]. Circ Res, 1998,82(7):739 50. 郭洪波;王帅;邹飞.;下丘脑神经元钙激活钾通道的温度效应[J]
- Methods Whole cell patch clamp technique was used to test the effects of Pho and Fen on TTX-S and TTX-R sodium currents in DRG neurons. 方法应用膜片钳技术研究氰戊菊酯和辛硫磷对DRG河豚毒素敏感(TTX-S)和不敏感(TTX-R)型钠通道的作用。
- ConclusionLoureirin B significantly inhibits the TTX-R sodium currents and perhaps the inhibition is one of the ease pain mechanism of Loureirin B. 结论龙血素B显著抑制TTX-R钠电流,且这种抑制作用发生在钠通道的失活过程而非激活过程,这种作用可能是其镇痛作用的机理之一。
- There was no any effect of Pho on the TTX-S and TTX-R sodium channels.The mixed treatment of a Pho and Fen did not show joint effect on the sodium currents. 辛硫磷对这两种亚型钠通道无明显影响,将氰戊菊酯和辛硫磷混配使用后,仅见氰戊菊酯作用的表现,未见氰戊菊酯和辛硫磷的联合作用。
- The present study was to investigate the changes of TTX R sodium currents and NaN/SNS2 sodium channel transcripts in DRG neurons in chronic constriction injury (CCI) of sciatic nerve 14 days after surgery. 目的 :观察电压门控钠通道NaN /SNS2在大鼠坐骨神经慢性压迫性损伤 (chronicconstric tioninjury ,CCI) 14天后的变化 ,探讨慢性神经痛的发生机制。
- Aim To investigate the effects of imidapril (IMI) on effective refractory period (ERP) and sodium current (I_(Na)) of myocytes in ventricular noninfarction zone of healed myocardial infarction (HMI) in rabbit models. 目的探讨咪达普利(IMI)对家兔陈旧性心梗(HMI)后心脏有效不应期(ERP)及钠电流(I_(Na))的影响。
- A man appeared at the castle gate in the guise of a woodcutter. 一个男子打扮成樵夫的模样出现在城堡的门口。
- Did you remember to padlock the gate? 你是否记得用挂锁把大门锁上?
- Keywords brucine;sodium current;hippocampal neuron; 马钱子碱;钠通道;海马神经元;
- I saw him make by the gate on his bicycle. 我看见他骑自行车从大门旁边过去了。
- The truck came to a dead stop out of the gate. 那辆卡车在大门外突然停下。