Hyperexcitability of neurons plays a critical role in the generation of neuropathic pain, and appears to be intimately linked to the plasticity of voltage - gated sodium channel subunits.

• 大量研究表明,神经元的异常兴奋是神经性疼痛产生的主要原因之一,并且这种异常兴奋与钠离子通道亚单位的可塑性有关。