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- DNA repair pathways can enable tumor cells to survive DNA damage induced by anti-tumor drugs such as alkylating agents. DNA损伤修复能够使肿瘤细胞耐受化疗药物造成的DNA损伤而存活,因此,调节某种特殊的DNA修复路径可以增强化疗药物的疗效。
- Therefore, modulating specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. 另外,有些DNA修复路径在一些肿瘤细胞中是失活的。
- There are several reasons why this might be, including the capacity of hypoxia to drive genomic instability and alter DNA damage repair pathways. 有很多原因可以解释,包括:乏氧驱使基因组不稳定性及改变DNA损伤修复通路的能力。
- In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. 此外,在肿瘤发展过程中出现的DNA修复通路的转变可以使一些癌细胞依赖于DNA修复通路的减少而得以生存。
- Most members of the XRCC genes family participated in several DNA repair pathways, including base excision repair, homologous recombination repair and non-homologous end joining. 目前已鉴定的这一基因家族的多数成员均参与几种重要的DNA修复途径,包括碱基切除修复、同源重组修复和非同源末端重接。
- Repair Pathways in Response to DNA Double-Strand Breaks DNA双链断裂损伤修复系统研究进展
- In a word, the FANCD2 activity adjusted exquisitely by ubiquitination and/or deubiquitination in vivo may co-regulate the FA pathway involving in variant DNA repair pathway. 机体很可能在不同信号通路对FANCD2泛素化/去泛素化的精细调节下,调控FA途径参与不同的DNA修复过程。
- In response to this accumulation, called ER stress, the cells activate a repair pathway to fix the problem, either derailing or halting the cell’s death cascade. 这种积累引起的反应,称作内质网应激,应激状态下细胞激活修复信号通路,通过破坏或是终止细胞死亡,去解决折叠中间体积累的问题。
- She turned the chair on its side to repair it. 她把椅子翻转过来修理。
- Damage tolerance:A post-replicative repair pathway in which the lesions are not repaired, but bypassed(tolerated) during replication. 损伤忍耐:是一种后复制修复途径,在修复过程中其中损伤没有被修复,而是被绕过(忍耐)过去。
- I have to wait in for the repair man. 我只得在家里等修理工。
- I'm all at sea; I've no idea how to repair cars. 我手足无措,不知道怎样修理汽车。
- John managed to repair his car by himself. 约翰设法独力修理自己的汽车。
- The lorry was damaged beyond hope of repair. 卡车严重损坏,已无修复的希望。
- Dust the repair to prevent adhesion to outer cover. 清整修补处以防与外胎粘连。
- I'm afraid this old radio is beyond repair. 恐怕这台旧收音机不能修了。
- He took the watch apart to repair it. 他把手表拆开来修理。
- The repair man have come to mend the photocopier. 修理工已经来修理这台影印了。
- The Waterloo line is closed for repair. 滑铁卢铁路线因维修关闭。
- Do you know how to repair a radio? 你知道怎么修收音机吗?