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Some progress has been achieved in this field and recent development of proteasome inhibitors are reviewed. 在此对蛋白酶体的结构、功能及其抑制剂的研究进展进行综述。
The expression of MHC I molecules on the muscle cells can be inhibited by the proteasome inhibitors lactacystin and MG132. 用蛋白酶体抑制剂抑制可以明显阻断肌细胞MHC I分子的表达；
Furthermore,the effect of proteasome inhibitors and TAP on particle antigens cross presentation was investigated by FACS analysis. 进而,采用流式细胞技术研究了不同蛋白酶体抑制剂以及TAP对噬菌体颗粒抗原交叉呈递的影响。
The recent progress of boronic acid derivatives used as enzyme inhibitors is reviewed focused on the serine protease inhibitors, proteasome inhibitors, and arginase inhibitors. 综述了有机硼酸类化合物作为酶抑制剂的研究进展,重点介绍了近年来发现的丝氨酸蛋白酶抑制剂、蛋白酶体抑制剂和精氨酸酶抑制剂。
Objective To explore the role of proteasome inhibitor 3,4-dichloroisocoumarin(DCI) on apoptosis of human gastric cancer cell line BGC823. 目的:探讨蛋白酶体抑制剂3,4-二氯异香豆素(DCI)对人胃癌细胞系BGC823体外增殖和凋亡的影响。
AIM: To investigate the effect of proteasome inhibitor MG132 on the proliferation and apoptosis of dopaminergic PC12 cells. 蛋白酶体抑制剂；PC12细胞；帕金森病；
It was confirmed that proteasome inhibitors have activities against a variety of malignancies.Bortezomib, the first proteasome inhibitor, obtained permission of clinical trial and on sale. 研究证实，蛋白酶体抑制剂对许多恶性肿瘤有抗癌活性，第一个获准临床试验和上市的蛋白酶体抑制剂硼替佐米治疗多发性骨髓瘤患者获得了较高的总体有效率和完全缓解率。
As a proteasome inhibitor, bortezomib has shown inhibition on cell proliferation, inducing cell apoptosis, inhibition of cell adhension and inhibition of tumor angiogenesis for multiple myeloma cells. 硼替佐米作为一种蛋白酶抑制剂，对多发性骨髓瘤细胞表现出抑制细胞生长、诱导肿瘤细胞凋亡、抑制细胞粘附、抑制肿瘤血管生成等作用，同时对血液系统其他恶性肿瘤具有显著的作用。
The therapeutic effects of proteasome inhibitors on gastrointestinal neoplasm 蛋白酶体抑制剂对胃肠道肿瘤的治疗作用
Relationship Between Proteasome Inhibitor and MyocardialReperfusion Injury 蛋白酶体抑制剂与心肌再灌注损伤
Proteasome inhibitor: anti-tumor activities and clinical application 蛋白酶体抑制剂的抗肿瘤作用及其临床应用
Keywords Reperfusion injury;Proteasome inhibitor;Acute myocardial ischemia; 再灌注损伤;蛋白酶体抑制剂;急性心肌缺血;
Keywords Proteasome inhibitors;Protected aminoalkyl sulfinyl dilactone;Synthesis; 蛋白酶体抑制剂;保护的氨烷基亚磺酰双内酯;合成;
Preventive and therapeutic effects of proteasome inhibitor MG-132 on denervated muscle atrophy of rats 蛋白酶体抑制剂MG-132对大鼠失神经肌萎缩的防治作用
Synergistic Effects of Proteasome Inhibitor on TRAIL-induced Apoptosis in Malignant Lymphoma Cells 蛋白酶体抑制剂在TRAIL诱导恶性淋巴瘤细胞凋亡中的协同作用
The Effect and mechanism of proteasome inhibitor induced cell cycle reentry on dopaminergic neurons 蛋白酶体抑制剂诱导多巴胺能神经元重启细胞周期的作用及机制
Keywords degradation of protein;myotube;skeletal muscle;dexamethasone;proteasome inhibitor;MG132; 蛋白降解;肌管;骨骼肌;地塞米松;蛋白酶体抑制剂;MG132;
Influence of Proteasome Inhibitor MG-132 on Myocardial Ischemia Reperfusion Injury in Rats 蛋白酶体抑制剂MG-132对大鼠心肌缺血/再灌注损伤的影响研究
Keywords Parkinson s disease Ubiquitin-proteasome system Proteasome inhibitor Lactacystin SH-SY5Y; 帕金森病;泛素-蛋白酶体系统;蛋白酶体抑制剂;
Keywords cell arrays;protein localization;ubiquitin;Proteasome inhibitor;substrate; 细胞微阵列;蛋白质定位;泛素;蛋白酶体抑制剂;底物;