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The first signal is specific, which T cell receptor could recognize and bind MHC molecule by antigen presenting cells. 第二信号是由T细胞上的CD28与抗原呈递细胞上的B7分子的结合而提供的。
Because thymic dendritic cells are the potent antigen presenting cells in the thymus, they must play an important role in thymic negative selection. 胸腺树突状细胞作为胸腺内功能强大的抗原呈递细胞,在阴性选择中必定发挥着不可忽视的作用。
Relationship between costimulatory molecule CD80/CD86 expressing on antigen presenting cells and spontaneous abortion. 抗原递呈细胞表面共刺激分子CD80/CD86表达与自然流产的关系
Dendritic cells (DCs) are one of the most potent antigen presenting cells (APCs). 树突状细胞(DC)是目前已知的功能最强的专职抗原提呈细胞。
HLA-DR~+ antigen presenting cells(APC) reduced remarkably in the SARS spleen white pulp. 脾白髓中HLA-DR+抗原呈递细胞明显减少。
Dendritic cells are the most powerful antigen presenting cells,which plays very important effect in immune system. 树突状细胞是体内最强的抗原呈递细胞,在免疫系统中发挥着重要的作用。
Aim: To explore the distribution of antigen presenting cells(APC) in mouse iris-ciliary body (ICB) after allogeneic bone marrow transplantation (BMT). 目的:观察异基因骨髓移植后小鼠虹膜睫状体内抗原递呈细胞(APC)的分布情况。
Through the T cells receptors (TCRs), CTLs can recognize the MHC class I-associated peptides complex on surface of the antigen presenting cells (APCs) such as malignant cells. CTL通过其T细胞受体特异性识别抗原提呈细胞(antigen-presenting cells,APCs)(如肿瘤细胞)表面的主要组织相容性复合体(major histocompatibility complex, MHC)-I类分子-肽复合物,然后自身得以活化,并最终通过多种机制杀死靶细胞。
Recently, dendritic cells (DCs) are found to play a dual role in the immunological system. Apart from inducing immune response as antigen presenting cells (APCs), DCs can also induce central and peripheral tolerance. 近年来，树突状细胞(dendritic cells,DCs)被发现在免疫系统中扮演着双重角色，除作为抗原提呈细胞(antigen presenting cells,APC)诱发免疫反应外，还能诱导中枢或周围性免疫耐受。
K562-B7-DCs induced by GM-CSF, IL-4 and IL-12 have the function of antigen presenting cells, and can help T lymphocyte to execute the anti-tumor effect, therefore enhancing anti-tumor immunity. 细胞因子联合诱生的K562-B7-DC能有效的执行其抗原提呈功能,同时协同T淋巴细胞发挥其抗肿瘤免疫作用。
In recent years, attenuated intracellular bacteria have elicited great concerns as vehicles for DNA vaccine delivery. DNA vaccines can be directly delivered into antigen presenting cells (APCs) by this means. 近年来，应用减毒胞内菌作为DNA疫苗的运送载体受到广泛关注，由于该途径可以通过减毒胞内菌将DNA疫苗定向运送至抗原提呈细胞(APCs)内，因而大大提高了DNA疫苗的摄入效率。
This review focuses on recent advances in understanding the CD4+ CD25+ regulatory T cells, chemokine and receptor, chemokine receptor expressing on CD4+ CD25+ Tr cells and the attraction of these cells by antigen presenting cells (APCs). 了解CD4+CD25+Tr细胞、趋化性细胞因子、趋化性细胞因子受体和表达于CD4+CD25+Tr细胞上的趋化性细胞因子受体以及它们与不同的抗原提呈细胞(APCs)之间的作用的最新研究进展十分必要。
DNA vaccine delivered by attenuated intracellular bacteria can be directly delivered into special antigen presenting cells (APCs), so it improves the efficiency of DNA vaccine to a great extent. 运用减毒胞内菌运送DNA疫苗能够将DNA直接运送到专业性抗原提呈细胞(APC)内,大大提高了DNA疫苗的摄入效率。
Dendritic cells (DCs) are the most potent antigen presenting cells (APCs) that prime naive T lymphocytes and active antigen specific cytotoxic T lymphocytes(CTLs), which makes DC a promising tools for immunotherapy of cancer . 树突状细胞(Dendritic Cells,DCs)作为功能最强的抗原提呈细胞，在恶性肿瘤的免疫治疗中起着重要的作用。
Tumor cells may escape immune surveillance due to lack of costimulatory singal which is essential for the activation of host immune system. Effective activation of T lymphocytes requires two signals from antigen presenting cells (APCs). 肿瘤免疫学研究表明：肿瘤逃避机体免疫监视的机制之一可能是因为肿瘤细胞表面缺乏使T细胞完全活化的共刺激信号。
The abnormal expression of CD28 and CD80 on PBMC in patients with active SLE suggests an abnormal signal pathway between antigen presenting cells(APCs) and T cells in SLE patients. SLE患者外周血T细胞及APC间存在异常的CD28－CD80。
Expression of IDO in dendritic cells (DC),the most powerful or "professional" antigen presenting cells,can suppress T-cell responsiveness via influencing the phenotype and function of DCs. 而树突状细胞(DC)是专职的抗原提呈细胞,IDO在其内的表达可影响DC的表型和功能,进而抑制T细胞的免疫反应。
B7 transfected CHO cells were used as artificial antigen presentation cells (APCs) in MLR to exclude the effects of other costimulatory molecules. 为了排除其它粘附分子的作用 ,应用联合转染DR7或 (和 )B7分子基因的CHO细胞系作为人工抗原递呈细胞 (APC)介导混合淋巴细胞反应 (MLR)。
If antigen present cells (APCs) provide MHC-peptides only, do not present costimulatory signals such as CD80 and CD86 to T lymphocytes at the same time, T lymphocytes will became anergy, immune tolerance will be induced. 如果抗原提呈细胞(antigen present cell，APC)只提供MHC-抗原肽复合物而不提供CD80、CD86等共刺激信号，将使淋巴细胞无能，诱导免疫耐受。
As we all know, antigen recognition. procession, presentation and T cells pulsing and activating all rely on the participationof antigen presenting cells (APCs). 抗原的识别、加工、提呈以及T细胞的致敏、激活和扩增都依赖于抗原递呈细胞（APCs）的参与。