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Keywords arsenous oxide;HAS-nanoparticles;monoclonal antibody;Targeting antitumor drugs;M3 acute promyelocytic leukaemia; 白蛋白纳米球;单克隆抗体;靶向性抗癌药;急性早幼粒细胞白血病;
acute promyelocytic leukaemia 急性前髓性白血病
Tretinoin, the first successful differentiating agent, approved by FDA for use in acute promyelocytic leukemia. fda批准首个有效的促分化药物-维A酸治疗急性早幼粒细胞白血病.
The CR rate was lower in acute promyelocytic leukemia (APL) patients with FLT3/ITD (P=0.015). 在M3患者中;FLT3/ITD阳性者完全缓解率低(P=0.;015)。
Tretinoin, the first successful differentiating agent, approed by FDA for use in acute promyelocytic leukemia. fda批准首个有效的促分化药物-维A酸治疗急性早幼粒细胞白血病.
Patients with certain subtypes of AML, such as acute promyelocytic leukemia (APL) have a higher chance of cure. 急性髓细胞性白血病（AML）的分型也影响其治愈率，如急性早幼粒细胞白血病(APL)的治愈率相对较高。
Mar RA,Raymond P,Warrell J.Two cases of extramedullary acute promyelocytic leukemia.Cancer,1994,74:1882. 游慧萍;马旭东;叶宝国.;急性早幼粒白血病以皮肤浸润为髓外复发首发症状2例
Recently,Use of arsenic trioxide (As2O3) in the treatment of drug resistant acute promyelocytic leukemia(APL)has achieved signifcant effects. 近年来，氧化砷(As_2O_3)用于治疗耐药性急性早幼粒细胞白血病(APL)取得了令人满意的疗效。
Objective To observe the clinical effects of all-trans-retinoic acid(ATRA)in treating 11 patients with acute promyelocytic leukemia(APL). 目的观察11例急性早幼粒细胞性白血病患者经全反式维甲酸治疗后的临床效果。
Arsenic trioxide (AS2O3) is a novel chemotherapy agent to succeed in treating acute promyelocytic leukemia(APL) firstly in China. 三氧化二砷(AS_2O_3)是我国率先应用于治疗急性早幼粒细胞白血病(APL)的药物，研究表明它能降解染色体t(15；17)的PML/RAR。
Arsenic trioxide (As2O3) has shown itself to be an effective and relatively safe agent for the treatment of acute promyelocytic leukemia (APL). 三氧化二砷(As_2O_3)治疗急性早幼粒性白血(APL)已取得很好的效果。
Many experiments in vitro and clinic researches had shown that arsenic trioxide can induce apoptosis of acute promyelocytic leukemia (APL) cells. 大量体外实验和临床研究表明：三氧化二砷(Arsenic trioxide,As_2O_3)可诱导急性早幼粒细胞白血病(Acute Promyelocytic Leukemia,APL)细胞凋亡。
IntroductionAll-trans retinoic acid (ATRA) is efficiently differentiation in-ducer for acute promyelocytic leukemia ( APL) . 全反式维甲酸(ATRA)用于急性早幼粒细胞白血病(APL)的诱导分化治疗，有很高的完全缓解(CR)率，现已成为APL诱导缓解治疗的首选药物。
Induction differentiation therapy of using All-trans retinoic acid has already been the first line therapy for acute promyelocytic leukemia. 全反式维甲酸诱导分化治疗已成为急性早幼粒细胞白血病的首选治疗手段。
Objective]To observe the effect of Scorpio extract on progranulocyte(HL 60) in acute promyelocytic leukemia and the correlative gene. [目的]观察全蝎提取液对急性早幼粒细胞株(HL-60)细胞及相关基因的影响。
Objective To observe cytogenetic and molecular genetic mechanism of acute promyelocytic leukemia(APL) switching to acute monocytic leukemia (AML-M5). 目的探讨儿童急性早幼粒细胞白血病(APL)治疗后转为急性单核细胞白血病(AML-M5)的细胞遗传学和分子遗传学机制。
Zhao WL, Chen SJ, Shen Y, et al. Treatment of acute promyelocytic leukemia with arsenic trioxide: clinical and basic studies [J] .Leuk Lymphoma ,2001,42(6): 1265. 周晋;孟然;王巍;等.;三氧化二砷治疗急性早幼粒细胞白血病心脏毒性的研究[J]
Objective To investigate the therapeutic effect and adverse effect of arsenic trioxide(As2O3)for patients with newly diagnosed acute promyelocytic leukemia(APL). 目的探讨三氧化二砷(As2O3)治疗初诊急性早幼粒细胞白血病(APL)的疗效与不良反应。
Huang SY,Chang CS,Tang JL,et al.Acute and chornic arsenicpoisoning associated with treatment of acute promyelocytic leukemia[J].Br J Haematol,1998,103:1092. 张鹏;王树叶.;三氧化二砷治疗急性早幼粒细胞白血病7年总结--附242例分析[J]
The FMPV, Fbg in the acute promyelocytic leukemia (APL) with disseminated intravascular coagulation (DIC) group were obviously lower than in the APL non DIC group( P <0.05). 急性早幼粒细胞白血病 (APL)伴弥散性血管内凝血 (DIC)较 APL 不伴 DIC组的 FMPV、Fbg明显减低 ;差异有显著意义 (P<0 .;0 5 )。