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- Down-regulateon of glutamate receptor 2 mRNA could lead to formation of GluR2-lacking, Ca2+-permeable AMPA receptors and increased toxicity of endogenous glutamate, which may be involved in the mechanisms of thedelayed neuronal death. 结论 我们的研究显示，成年大鼠癫痫持续状态后海马神经元发生的是选择性的、迟发性的损伤，而AMPA受体的亚单位谷氨酸受体-2的下调形成了Ca~(2+)渗透性的AMPA受体，增加了内源性谷氨酸的兴奋毒性，可能参与了迟发性神经元损伤的机制。
- Roles of glutamate receptor 2 and cellular free calcium in the pathogenesis of periventricular leukomalacia 谷氨酸受体2和钙离子在新生大鼠脑室周围白质软化症发病机制中的作用探讨
- Reduced expression of metabotropic glutamate receptor 2 mRNA in T cells of ALS patients ALS患者T细胞中代谢型谷氨酸受体2mRNA的表达减少
- Keywords AMPA receptor;Glutamate receptor 2;Calcium;Periventricular leukomalacia;Hypoxia-ischemia;Neonatal rats; AMPA受体;谷氨酸受体2;钙;脑室周围白质软化;脑缺氧缺血;新生大鼠;
- Glutamate receptor 2 谷氨酸受体2
- AIM To study the changes and effects of metabotropic glutamate receptor subtype 2 (mGluR2) in diffuse brain injuries (DBI) coupled with secondary brain insults (SBI) in rats. 目的 研究弥漫性脑损伤 (diffusebraininjury;DBI)及其合并二次脑损伤 (secondarybraininsults;SBI)后大鼠脑皮层代谢性谷氨酸受体 2亚型 (mGluR2 )的变化及其意义 .
- The ionotropic glutamate receptor antagonists D-AP5 and CNQX could not fully block the action of ACM. 离子型谷氨酸受体拮抗剂D-AP5和CNQX不能完全阻断条件培养基的作用。
- DAO is expressed in the human brain, where it oxidizes D-serine, a potent activator of NMDA glutamate receptor. DAO表达在人的大脑中，它可以氧化D-丝氨酸，后者则是一个强力的NMDA谷氨酸受体激活剂。
- AIM To study the changes and effects of metabotropic glutamate receptor subtype 4 (mGluR4) after diffuse brain injuries (DBI) coupled with secondary brain insults (SBI) in rats. 目的 研究弥漫性脑损伤 (DBI)及其合并二次脑损伤 (SBI)后大鼠脑皮层代谢型谷氨酸受体亚型 4(m Glu R4)的变化及意义 .
- Howlett found the fruit fly's metabotropic glutamate receptor (DmGluRA) gene, when mutated, increased the excitability of the neuron by preventing PI3K from doing its job. 赫尔特发现当果蝇的亲代谢性谷氨酸盐受体基因发生突变时，将通过阻止PI3K的作用来增加神经元的兴奋性。
- Tra2 is an SR-like protein that has several isoforms and, regulates the alternative pre-mRNA splicing of many important genes, including the glutamate receptor. Tra2（splicing factor Transformer-2）是一种SR相关蛋白的选择性剪接因子，有多种亚型，Tra2参与包括谷氨酸受体在内的很多重要基因前体mRNA的选择性剪接。
- The gene with the strongest association was fibroblast growth factor receptor 2, or FGFR2. 这些基因与纤维母细胞生长因子受体2（FGFR2）强烈相关。
- During both in vivo and in vitro development, CGC depend on the activity of the NMDA glutamate receptor subtype for survival and full differentiation [3]. 在体内和体外发育过程中，小脑颗粒细胞依赖于N-甲基-D-天冬氨酸(NMDA)谷氨酸盐受体亚型的活性而生存和完全分化。
- The gene whose ariants appears to confer the greatest risk of the four is fibroblast growth factor receptor 2, or FGFR2. 四个基因中致病能力最强的似乎是成纤维细胞生长因子受体2型基因，即FGFR2。
- Abstract:[/b] The risk of cluster headache (CH) is associated with the Gallele of the G1246A polymorphism in the hypocretin receptor 2 (HCRTR2) gene. 摘要：丛集性头痛的危险与食欲素受体2的G1246A等位基因多形性有关。
- Our finding implicates functional importance of histidine in exchange of arginine at amino acid 481 of transferrin receptor 2 in iron homeostasis. 我们发现转铁蛋白受体2的第481个组氨酸的在维持体内铁代谢平衡的重要作用。
- Abstract: The risk of cluster headache (CH) is associated with the G-allele of the G1246A polymorphism in the hypocretin receptor 2 (HCRTR2) gene. 摘要：丛集性头痛的危险与食欲素受体2的G1246A等位基因多形性有关。
- More precisely, they block the action of a form of glutamate receptor known as the NMDA receptor, which plays a critical role in brain development, learning, memory and neural processing in general. 说得更精确些，这些药物阻断了一种叫做NMDA型的麸胺酸受体，该受体对于大脑的发育、习、忆以及一般的神经活动都扮演著举足轻重的角色。
- The N-methyl-D-aspartate receptor (NR), a subtype of ion-tropic glutamate receptor, provides sites for phosphorylation and for channel blocking. NRs are composed of NR1 and NR2A-D subunits. 现已发现NMDAR至少存在7个亚单位,即NR1亚单位、4种NR2亚单位(分为NR2A、NR2B、NR2C和NR2D)以及2种NR3亚单位。
- Objective To predict binding domains of human C5a like receptor 2(C5L2) and further to detect the affinity between C5a and C5L2 by the technology of bioinformatics and BIA. 目的通过生物信息学分析人C5L2受体的配体结构域,并进一步利用生物分子相互作用测定技术(biomo-lecular interaction analysis,BIA)研究其与配体C5a分子间的相互作用。
