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- Results: Significant improvement of dissolution of tolbutamide was found. 结果:甲苯磺丁脲片的溶出度有很大程度提高。
- Methods: L-HPC was added into tolbutamide and its dissolution was measured. 方法:于甲苯磺丁脲中加入低取代羟丙基纤维素测定溶出度。
- Objective: To change the dissolution of the tolbutamide tablet by adding L-HPC. 目的:采用低取代羟丙基纤维素改变甲苯磺丁脲片的溶出度。
- Tolbutamide, indomethacin and diclofenac interacted with each other, resulting in the decreased formation of metabolites catalyzed by CYP2C9. 底物药物甲苯磺丁脲、双氯芬酸和吲哚美辛之间存在代谢相互作用，导致生成相应代谢物的产率降低。
- OBJECTIVE To develop a method for separating and purifying the two main metabolites of tolbutamide, carboxytolbutamide (CTOL) and hydroxytolbutamide (OTOL), from human urine, then identify the production and determine its purity. 目的研究从生物体液(尿液)中分离纯化甲苯磺丁脲的两个主要代谢物羟基甲苯磺丁脲(OTOL)和羧基甲苯磺丁脲(CTOL)的方法,并对所得的产物进行鉴定和含量测定。
- intravenous tolbutamide tolerance test 静脉甲磺丁脲耐量试验
- Methodical study in improving dissolution of tolbutamide tablet 提高甲苯磺丁脲片溶出度方法的研究
- Keywords anemam（AM）;tolbutamide;blood glucose;rabbit.; 关键词知母多糖;甲苯磺丁脲;血糖;家兔;
- Keywords P450 2C9;Genetic Polymorphisms;DNA microarray;Tolbutamide;Glimepiride; 基因多态性;基因芯片;甲苯磺丁脲;格列美脲;
- Separation and Purification of Metabolites of Tolbutamide by Preparative Liquid Chromatography 甲苯磺丁脲主要代谢物的高效液相色谱分离纯化
- Keywords tolbutamide;IS-HPC;sodium laurylsul fonate;integrating time limit;dissolution; 甲苯磺丁脲;低取代羟丙基纤维素;十二烷基磺酸钠;崩解时限;溶出度;
- Keywords reversed phase high-performance liquid chromatography;tolbutamide;human plasma;content determination; 反相高效液相色谱;甲磺丁脲;人体血浆;含量测定;
- HPLC assay for tolbutamide and its metabolites in biological sample by solid phase extraction and study of its pharmacokinetics in human 固相萃取HPLC检测生物样品中甲苯磺丁脲和代谢产物及其人体药代动力学研究
- Poisoning by tolbutamide 甲苯磺丁脲中毒
- tolbutamide sodium 甲磺丁脲钠, 甲糖宁钠:作用与其基质同, 静脉注射用于糖尿病的诊断试验
- tolbutamide test 甲磺丁脲试验, 甲糖宁试验
- tolbutamide tolerance test 甲苯磺丁脲(甲糖宁); 耐量试验; 静脉甲苯磺西脲试验; 甲苯磺丁脲耐量试验
- tolbutamide n. 甲糖宁(一种治糖尿病的药)
- Sodium Tolbutamide 甲磺丁脲钠, 甲糖宁钠[降血糖药]
- Orinase Diagnostic 甲苯磺丁脲钠粉针剂
