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Human apoE4 has been found in senile plaques (SPs) and neurofibrillary tangles (NTFs) in AD brains. 研究进一步表明，AD患者脑内的老年斑和神经原纤维缠结中存在有较多的载脂蛋白E4(apolipoprotein E4,apoE4)。
Segmentation of senile plaques and neurofibrillary tangles is crucial to pathological analysis of Alzheimer's disease. 老年斑和神经元缠结的分割提取对于阿尔茨海默症病理研究有重要的意义。
Upon autopsy, the presence of amyloid plaques and neurofibrillary tangles is used to positively diagnose Alzheimer's disease. 经过尸体解剖，淀粉质色斑的出现和神经原纤维的混乱状态被用来确诊阿兹海默症。
Definitie diagnosis requires postmortem identification of amyloid plaques and neurofibrillary tangles linked to the disease. 最终确诊需要尸检发现与本病相关的淀粉样蛋白斑及神经纤维缠结。
Neurofibrillary tangles develop when microtubule tau proteins become hyperphosphorylated and aggregate within the neuronal cells. 这些(神经细胞内)神经纤维纠结，会分解瓦解神经元沿轴突运输分子的能力。
In Alzheimer's disease brain cells degenerate, brain mass shrinks and characteristic neurofibrillary tangles and neural plaques are seen post mortem. 而在早老性痴呆症患者死亡后检验发现有脑细胞退化、脑组织缩小、典型的神经原纤维纠结及神经斑块等现象。
To his surprise, Barrio found that FDDNP had a specific affinity for the neurofibrillary tangles and beta-amyloid plaques found in the brains of Alzheimer's patients. 参与研究的人员是核医学专家，他们使用放射性化合物对人体内部组织进行造影。为此，他们设计和建立了一种叫做FDDNP的分子。
Here are neurofibrillary tangles in neurons of a patient with Alzheimer's disease. The cytoskeletal filaments are grouped together in the elongated pink tangles. 图示阿尔茨海默病人神经原纤维排列紊乱。细胞骨架微丝杂乱的聚集在变长（箭头示）的粉红色区域中。
Here are neurofibrillary tangles in neurons of a patient with Alzheimer's disease.The cytoskeletal filaments are grouped together in the elongated pink tangles. 图示：阿尔茨海默病神经原纤维缠结细胞骨架微丝杂乱的聚集在变长（图示）的粉红色区域中。
Firstly,a modified fuzzy C means method is used on the RGB color space to identify senile plaques and neurofibrillary tangles in microscopic image of the hippocampus separately. 利用改进的模糊C均值算法对彩色图像的颜色信息进行聚类,分别提取了老年斑和神经元纤维缠结目标。
The basic principles of Al harming to intellect of human were studied.The results show that Al can enter cerebrum and combine with brain neurofibril to form neurofibrillary tangles and senile spots. 铝对人类智能危害的基本原理是铝可进入大脑，与脑神经结合形成脑组织神经原纤维缠结和老年斑。
His financial affairs are in such a tangle. 他的钱财是糊涂帐。
Abnormal deposition of senile plaques (SP), neurofibrillary tangles (NFT) , synapse loss and neuronal cell death are pathological changes which are commonly found in AD patient’s brain. AD患者脑中典型的病理改变包括老年斑(SP)的异常沉积、神经原纤维缠结(NFT)、突触丧失以及神经元的死亡。
The wool got in a fearful tangle. 毛线乱成了一团。
Alzheimer s disease(AD)is a progressive neurodegenerative disease.AD is characterized by recent memory impairment.Its pathological characteristics are senile plaque and neurofibrillary tangles(NFT). 阿尔茨海默病(AD)是以近期记忆障碍为主要临床症状,以老年斑及神经纤维缠结为主要病理改变的进行性神经变性疾病。
There is a tangle of ropes on the deck. 甲板上有一团乱绳。
If I were you, I wouldn't tangle with them. 我要是你,我就不跟他们争吵。
The boy got into a tangle over the rules of the game. 男孩子们在比赛规则上发生了争吵。
Her hair get all tangle up in the barbed wire fence. 她的头发让刺钢丝篱笆都给挂住了。
Keywords Alzheimer's disease;Cellular prion protein;Gene Polymorphism;Senile plaque;Neurofibrillary tangle;Oxidative stress;Apoptosis;Neuroprotection; 关键词老年性痴呆;细胞型朊蛋白;基因多态性;老年斑;神经原纤维缠结;氧化应激;凋亡;神经保护;