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- PRODUCTION OF L DOPA BY IMMOBILIZED PSEUDOMONAS SP. 固定化假单胞菌产L-多巴
- Objective: To observe the effect of chronic levodopa (L dopa) administration on striatal prodynorphin mRNA expression in a rat model of Parkinson disease (PD), and probe into the pathogenesis of L dopa induced dyskinesias (LID). 目的 :观察左旋多巴 (L dopa)治疗对帕金森病 (PD )大鼠纹状体强啡肽原表达的影响 ,探讨L dopa诱发异动症 (LID)的机制。
- L dopa induced dyskinesia may disappear or be improved after PVP. 苍白球腹后部切开术使异动症得到了根本的缓解或消除，从而允许左旋多巴发挥最大的功效而无严重的副作用。
- AIM The purpose is to synthesize 6 fluoro L DOPA (FDOPA). 目的 :合成 6 氟 L多巴 (FDOPA)。
- After L dopa therapy,the level changes were enhanced ?(P<0.05)?. L-多巴治疗后 ;NO、NOS、SOD、GSH-Px进一步降低 ;LPO进一步增高 (P <0 .;0 5 )。
- Objective To study the neurotoxicity of L dopa and its neuroprotective method. 目的 研究左旋多巴 (L- dopa)的神经毒性及其神经保护方法。
- METHODS: The models of hypoprolactinemia were established with L dopa in rats. 方法 :采用左旋多巴 (L Dopa)诱导建立哺乳大鼠乳汁分泌低下模型 ;
- The practical technique was provided for the radiochemical synthesis and entiomeric purity of 6 [ 18 F ]fluoro L DOPA. 为 6 [1 8F] L 多巴的放射化学合成及其对映纯度的测定提供了可靠的技术
- Objective To introduce L dopa test into the preparation of the surgical intervention of PD. 目的 介绍左旋多巴试验在PD外科治疗中的应用价值。
- Objective To observe the change of antioxidant system in Parkinson disease(PD) and the influence of L dopa. 目的 观察帕金森病 (PD)血抗氧化系统变化及 L-多巴的影响。
- METHODS: Tyrosinase activity was estimated by measuring the oxidation rate of L DOPA. 方法 :酪氨酸酶多巴速率氧化法体外测定药物干预前后酪氨酸酶活性 ,求出酪氨酸酶抑制率。
- After in taking 350mg of L dopa,timed test and non timed test were done every 30 minutes. 先停药 12小时以上 ,然后 ,一次性口服左旋多巴 35 0mg ,每隔 30分钟对病人的状态评价一次 ,共计检查 30 0分钟 ;
- Mothods L dopa tests were conducted in 33 cases with PD,after UPDRS rating and Webster rating. 方法 对 33例PD病人 ,在进行UPDRS评分和Webster评分后 ,作一次单剂量左旋多巴试验。
- Large scale production of 6 FDOPA and automatic synthesis of 6 [ 18 F ]fluoro L DOPA with excellent chemical and entiomeric purity are available. 可大量合成 6 FDOPA ,使自动合成 6 [1 8F] L 多巴成为可能。
- AIM To study the synthesis and determination for enantiomeric purity of 6 fluoro L 3,4 dihydroxyphenylalanine (6 fluoro L DOPA, 6 FDOPA). 目的 合成 6 氟 L 多巴 (6 FDOPA) ,并测定其对映纯度。
- Isolated blood ring assays were used to study the changes of dopamine receptors in rat aorta vascular smooth muscles after oral L dopa. 采用离体血管环的方法对长期服用非亚型特异性拟多巴胺类药物左旋多巴后大鼠主动脉平滑肌中多巴胺受体两亚型（DA1，DA2）的变化进行了观察。
- Methods:The standard strains were grown on L dopa and bird seed medium.The fragment of CNLAC1 was analyzed by random amplification of genomic DNA. 方法:取标准的产黑素和白化突变菌株分别培养,研究产黑素表型的变化,并用聚合酶链反应进行CNLAC1目的基因片段的扩增。
- No statistical difference was observed in the improvement percentages of CBPVP, SBPVP1 and SBPVP2. CBPVP contributed greatly to L dopa induced side effects (part IV). 结果 CBPVP、SBPVP1以及SBPVP2均明显改善患者的整体病情和典型症状 (震颤、僵直和行动迟缓 ;P <0 0 0 1) ;它们对“关”状态的改善总是高于对“开”状态的改善。
- CaNa 2EDTA is only used for early manganism treatment. L dopa is effectively for manganism who has suffered from the rigidity and dystonia. However, the adverse effects can easily occur in long|term treatment of manganism when the two drugs are used. CaNa2 EDTA仅适用于早期轻症锰中毒的治疗 ,L dopa对具有肌肉僵直及肌张力障碍的锰中毒治疗有效 ,但这 2种药易出现副作用。
- Objective To explore the activities and the level of antioxidant system in Parkinson disease (PD) and the effect of L dopa and Vit E on it,and find the indications of oxidative stress in PD. 目的 探讨帕金森病 (PD)的抗氧化酶 (SOD)活性和过氧化脂质 (L PO)代谢水平的变化和多巴药物及 Vit E对其的影响 ,找出反映氧化异常的客观生化指标。
