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- Objective:To synthesize the aldose reductase inhibitor fidarestat. 目的:合成醛糖还原酶抑制剂非达司他。
- SNK-860 is a potent aldose reductase inhibitor with high ARJ activity and low side effects, which makes it a promising drug for diabetic neuropathy. SNK-860是一种新型的海因类醛糖还原酶抑制剂，对醛糖还原酶的抑制作用强而专一，而且不良反应小，是治疗糖尿病性神经病变的安全有效的药物。
- The synthesis of epalrestat,an aldose reductase inhibitor, was improved. The yield of its intermediate 3-carboxymethyl rhodanine was raised to 76.4%. 对醛搪还原酶抑制剂依帕司他的合成工艺作了改进，使中间体绕丹宁乙酸的收率提高到76．4%25。
- Conclusion The structure-activity relationships of methylquinolinoneacetic acids, as a novel type of aldose reductase inhibitor, should be investigated further. 结论 甲基喹啉酮乙酸类化合物作为新型醛糖还原酶抑制剂，其构效关系值得进一步研究。
- OBJECTIVE: To observe the effect of aldose reductase inhibitor(ARI) on the activity of corneal aldose reductase (AR) and Na+-K+ATPase , and on corneal lesions in early diabetic rats and to investigate the protective mechanism. 目的:观察醛糖还原酶抑制剂(ARI)对糖尿病早期大鼠角膜组织中醛糖还原酶活性(AR)、钠-钾-ATP酶活性(Na+-K+ATPase)和角膜病变的影响,并探讨其防治效应及其机制。
- Part IIThe second part of this thesis is the synthesis of the aldose reductase inhibitor SNK-860. SNK-860 is a potent aldose reductase inhibitor with high ARJ activity and low side effects, which makes it a promising drug for diabetic neuropathy. 本论文的第二部分是醛糖还原酶抑制剂SNK-860的合成研究。 SNK-860是一种新型的海因类醛糖还原酶抑制剂，对醛糖还原酶的抑制作用强而专一，而且不良反应小，是治疗糖尿病性神经病变的安全有效的药物。
- The considerable interest has been evoked in using of aldose reductase inhibitors as potential therapeutic ad... 醛糖还原酶抑制剂作为潜在的治疗心肌梗死的有效措施引起了研究者的关注。
- For screening aldose reductase inhibitors(ARI) from traditional medicinal herbs,the assay method of pig lens AR was established and 40 traditional medicinal herbs were screened. 为从大量中草药及其化学成份中筛选有效低毒的醛糖还原酶抑制剂（ARI），建立了猪晶状体AR的测定方法，其研究了知母等40种中药水提取液对AR的抑制作用。
- The considerable interest has been evoked in using of aldose reductase inhibitors as potential therapeutic adjuncts in treating evolving myocardial infarction. 醛糖还原酶抑制剂作为潜在的治疗心肌梗死的有效措施引起了研究者的关注。
- Aldose Reductase Inhibitor and Blood Vessel Restenosis 醛糖还原酶拮抗剂治疗大鼠血管再狭窄
- Keywords aldose reductase inhibitor;fidarestat;synthesis; 醛糖还原酶抑制剂;非达司他;药物合成;
- Keywords Aldose reductase inhibitor;Flavonoids;Pharmacophore model; 醛糖还原酶抑制剂;黄酮类化合物;药效团模型;
- According to investigations on animals, it is shown that TangLuoTong can anti-coagulate, thrombolysis, distend vessels, reduce blood viscosity and has actions like aldose reductase inhibitors. 经动物研究发现糖络通能抗凝、溶栓、扩张血管、降低血液粘度，并有一定的醛糖还原酶抑制剂样作用；
- Protective effects of aldose reductase inhibitor or myo-inositol on experimental diabetic retinopathy 醛糖还原酶抑制剂和肌醇对糖尿病视网膜毛细血管周细胞的保护作用
- Establishment of Screening Model for Aldose Reductase Inhibitor(ARI) from Chinese Herbal Medicine 中草药醛糖还原酶抑制剂筛选模型的建立
- Keywords epalrestat;aldose reductase inhibitor;3-carboxymethyl rhodanine;phase transfer catalyst;synthesis; 依帕司他;醛糖还原酶抑制剂;3羧甲基绕丹宁;相转移催化剂;合成;
- Keywords epalrestat;aldose reductase inhibitor;3-carboxymethyl rhodanine;synthesis; 依帕司他;醛糖还原酶抑制剂;绕丹宁乙酸;合成;
- Keywords microorganism;aldose reductase inhibitor;high throughput screening;structure determination; 微生物;醛糖还原酶抑制剂;高通量筛选;结构鉴定;
- Keywords Diabetic neuropathy;Aldose reductase inhibitor;Nerve growth factor;Neuropeptide; 糖尿病神经病变;神经生长因子;醛糖还原酶抑制剂;神经肽;
- Keywords aldose reductase inhibitors;polyphenyls;terpenes;diabetes mellitus; 醛糖还原酶抑制剂;多酚类;萜类;糖尿病;
