ZrO2 ceramic membrane was used in the work, and the average permeation flux could reach 150L/m2.h under pH value of 3, transmembrane pressure 0.1MPa, CFV 3m/s, and temperature higher than 70C.

• 为进一步提高肌苷得率，缩短提取工序，实验研究了絮凝剂预处理发酵液，解决碱性条件下由于蛋白析出导致膜污染加重的问题，研究表明采用CaCl_2絮凝并调节pH=11，可以获得平均渗透通量为180L/m~2h，肌苷得率大于95%25；