With the removal of oxygen from sickle hemoglobin, the red blood cell deforms into a sickled shape.This sickling damages the RBC membrane and increases the likelihood of rupture and anemia.

• 随着镰（状细胞贫血）珠蛋白中氧的去除，红细胞变形成镰状，红细胞膜受到破坏，破裂的可能性增加，从而导致贫血。