With the increasing doses of valproic acid sodium, the incidence of VPA induced spina bifida occulta became higher and the incidences of the malformation were 80% with 400? mg/kg, 93% with 450? mg/kg and 100% with 500?

• 丙戊酸钠诱导隐性脊柱裂畸形随药物剂量加大,畸形发生率升高,丙戊酸钠剂量400mg/kg、450mg/kg、500mg/kg诱导畸形发生率分别是80%25、93%25、100%25,腰椎对丙戊酸钠的致畸作用最敏感;