With the finding of the specific markers of lymphatic and lymphangiogenesis factors, tumor cells had been reported that they could induce lymphangiogenesis by autocrine or paracrine VEGF-C/D.

• 近年来随着淋巴管标记物以及淋巴管生成因子的发现,文章报道肿瘤细胞可通过自分泌或旁分泌内皮细胞生长因子C/D(VEGF-C/D),诱导肿瘤淋巴管生成,增加肿瘤淋巴道转移的几率。