We used the angiogenesis effect of hepatocyte growth factor to treat the PAD and found the growth of new vessels.But the safety was an important problem of gene therapy.

• 利用肝细胞生长因子促进血管生成的作用,采用质粒作为载体对大鼠和犬的下肢动脉闭塞疾病模型进行治疗,效果良好。