We treated eighteen patients with refractory acute lymphocyte leukemia with mitoxantrone, VP 16, Ara C (MEA) and extracted and analysed the nuclear matrix proteins by high salt and SDS PAGE before and after chemotherapty.

• 探索了用米托蒽醌、VP－16、阿糖胞苷联合化疗治疗难治性急性淋巴细胞白血病及其前后细胞核基质蛋白的变化。