We proved for the first time that the signal transduction system of I_1R was related to activation of PC-PLC,followed by accumulation of DAG and the activation of MAPK cascade process.

• 首次直接证实I1R的信号转导途径与活化PC-PLC继而产生DAG,其后引起丝裂原激活蛋白激酶(MAPK)酶促级联反应过程有关。