We first obtained a volume overload by creation of an aortic insufficiency, which was followed 14 days later by pressure overload induced by constricting the abdominal aorta.

• 先诱导主动脉瓣关闭不全，2周后腹主动脉缩窄，制造超容量负荷及压力负荷，利用心导管术和心脏多谱勒观察术前后家兔血流动力学及心脏结构和功能的变化。