We conclued: (1 )there is increased collagen content in glomeruli of SHR; and (2) accumulation of glomerular collagen may be the early lesion of glomerulosclerosis in SHR.

• 提示（1）SHR肾小球胶原沉积增加，（2）累积的肾小球胶原可能是肾小球硬化的早期病变。