Vincristine could affect the activity of p38 MAPK in gastric cancer cell SGC7901 and multidrug resistant cell SGC7901/VCR.

• p38MAPK信号转导途径可能与长春新碱的抗肿瘤活性相关 ,肿瘤细胞内 p38MAPK对长春新碱刺激的反应速度可能与胃癌长春新碱耐药相关