Useful in vivo models for testing of antifibrotics are rat secondary biliary fibrosis or the MDR2 KO mouse (chronic cholestatic liver disease)and reversion of fibrosis after withdrawal of a hepatotoxin like thioacetamide.

• 用于检测抗肝纤维化药物有效性的动物模型包括继发性大鼠胆汁性肝纤维化或者MDR2 KO小鼠模型(慢性淤胆性肝病)以及撤药以后可逆性的肝毒性肝纤维化如硫代乙酰胺肝纤维化模型。