Used ethinglestradiol(EE,0.05 mg per day for 20 days monthly for 20 women start at d 5 of menses) and 3 cyclopentyl 17 ethinystradilp ether (CEE 3,5 mg one time a month for 20 women) for half a year.

• 长效组及短效组分别给予尼尔雌醇 ( CEE3 ；5mg；每月一次 )、炔雌醇 ( EE；0 .；0 5mg；qd× 2 0 d；月经 d5开始服用 )治疗半年；对照组不用药；研究结束时Doppler超声检查。