Use a combination of an oral glucose-lowering drug( usually metformin) with NPH insulin twice daily( or once daily if initiated early), or twice-daily insulin mixes.

• 联合应用一种口服降糖药物（常是二甲双胍）NPH一日2次（始早期应用一日一次）或者一日两次胰岛素混和制剂。