Treatment with two oligonucleotides directed against the coding region and the translation initiation region of bcl 2 messenger RNA/VP 16 combination respectively for 48 h had significantly reduced the number of viable AL cells.

• 靶向 bcl- 2 m RNA翻译起始区与靶向蛋白编码区的两个反义寡核苷酸分别与 VP1 6 联合作用 AL 细胞 4 8h；细胞的生存受到明显的抑制 ；分别同无关寡核苷酸 (NS- ODN)联合 VP1 6 组、单用 VP1 6 组进行比较 ；差异有显著性 (P<0 .；0 5 )。