To research if the anti-cancer activity of DDN is p73 related. Contrasted by the missense oligonucleotide(MSODN) and DDN alone,we interference the effects of DDN(15uM) with TAp73-specific antisense oligonucleotide(ASODN).

• 选取一DDN药物较佳作用浓度（15uM）处理hela细胞，同时运用3条针对不同部位的TAp73特异性反义寡核苷酸进行干预，并以错义寡核苷酸干预组和DDN药物单独处理组为对照：运用RT-PCR方法验证我们对于TAp73/DNp73表达相对量的干预效果；