To establish in vit ro model of human cell carcinogenesis , the 3 cell types were characterized for their responses to induction of malignant t ransformation by different carcinogens.

• 使用致癌物诱发恶性转化以鉴别其不同类型细胞的反应,从而建立人类成纤维细胞肿瘤进展的体外模型。