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- Objective To detect the polymorphism in t he thymidylate synthase promoter enhancer region (TSER) in primary gastrointesti nal cancer. 目的检测原发性胃癌、结直肠癌胸苷酸合成酶(TS)启动基因增强子区段(TSER)的多态性。
- Using chromosome DNA of Lactobacillus casei 34103 as template, thy A (Thymidylate synthase) gene was amplified by PCR with pfu DNA polymerase. 以干酷乳杆菌L.;casei34103染色体DNA为模板,利用PCR技术扩增胸苷酸合成酶(Thymidy-1atesynthase,fhyA)基因,回收纯化。
- Objective To observe the expression of thymidylate synthase(TS) in gastric \{carcinoma\} and its relationships with clinicopathological characteristics and prognosis. 目的观察胃癌中胸苷酸合酶(TS)的表达情况及其与患者年龄、性别、分化程度、淋巴结转移及预后的关系,探讨TS的临床病理学意义。
- Objective To observe the expression of thymidylate synthase(TS)and thymidine phosphorylase(TP)in colorectal carcinoma and its relations with clinicopathological characteristics and prognosis. 目的观察结直肠癌中胸苷酸合酶(TS)、胸苷磷酸化酶(TP)的表达情况及其与患者年龄、性别、分化程度、淋巴结转移及预后的关系,探讨TS、TP的临床病理学意义。
- Keywords Colonic neoplasms;Thymidylate synthase;Single nucleotide;polymorphism; 结肠肿瘤;胸苷酸合酶;单核苷酸;多态性;
- Keywords Stomach neoplasms;Thymidylate synthase;Immunohistochemistry; 胃肿瘤;胸苷酸合成酶;免疫组织化学;
- Keywords nolatrexed;thymidylate synthase;protein expression;drug resistance; 洛拉曲克;胸苷酸合成酶;蛋白表达;耐药性;
- Association of thymidylate synthase polymorphism with esophageal squamous-cell carcinoma 食管癌与胸苷酸合成酶多态性的关联研究
- Determination of activity of new antifolate thymidylate synthase inhibitor ZD1694 against cancer cell lines in vitro 新一代抗叶酸胸苷酸合成酶抑制剂ZD1694的体外抗肿瘤活性(英文)
- Keywords DNA methyltransferase inhibitor;thymidylate synthase inhibitor;dru g combination;antitumor; DNA甲基化转移酶抑制剂;胸苷酸合成酶抑制剂;联合用药;抗肿瘤;
- Keywords folic acid antagonists;thymidylate synthase;methyl thiazolyl tatrozolium;neoplasms; 关键词叶酸拮抗剂;胸苷酸合成酶;甲基噻唑基四唑;肿瘤;
- Keywords medicinal chemistry;thymidylate synthase inhibitor;raltitrexed;synthesis; 药物化学;胸苷酸合成酶抑制剂;雷替曲塞;合成;
- Keywords Breast neoplasms;Thymidine phosphorylase;Thymidylate synthase;Dihydropyrimidine dehydrogenase;Prognosis; 乳腺肿瘤;胸苷磷酸化酶;胸苷酸合成酶;二氢嘧啶脱氢酶;预后;
- Keywords Esophageal neoplasms;Carcinoma;squamous cell;Thymidylate synthase;Gene polymorphism;Lymph node metastasis; 关键词食管肿瘤;癌;鳞状细胞;胸苷酸合成酶;基因多态性;淋巴结转移;
- Keywords WSSV,collagen,thymidylate synthase,DNA-binding protein,functional gene,gene clone and expression; 对虾白斑综合症病毒;胶原蛋白;胸腺嘧啶核苷酸合成酶;DNA结合蛋白;功能基因;克隆表达;
- Keywords gastric neoplasms;thymidylate synthase;thymidine phosphorylase;prognosis;fluoropyrimidines; 胃肿瘤;胸苷酸合成酶;胸苷磷酸化酶;预后;氟尿嘧啶;
- Keywords Gastric carcinoma;Colorectal neoplasm;Thymidylate synthase;Gene expression;PCR; 胃癌;结直肠肿瘤;胸苷酸合成酶;基因表达;多聚酶链式反应;
- Keywords Thymidylate synthase;Colorectal neoplasmas;Drinking;Genetic polymorphisms;Disease susceptibility; 胸苷酸合成酶;结直肠肿瘤;饮酒;基因多态性;易感性;
- Keywords Colorectal carcinoma;Thymidylate synthase;Dihydropyrimidine dehydrogenase;5-Fluorouracil; 结直肠癌;胸苷酸合成酶;二氢嘧啶脱氢酶;5-氟尿嘧啶;
- Keywords Colorectal neoplasms;Thymidylate synthase;Immunohistochemistry;Prognosis; 结直肠肿瘤;胸苷酸合成酶;免疫组织化学;预后;