Thus,the aim of this study was to characterize the effect on the antigen-presenting function of Kupffer cells by intrasplenic transplantation of GM-CSF gene-modified fetal liver cells (FLC-GM)in combination with IL-2 and 5-Fu.

• 方法 :以结肠癌肝转移小鼠为模型 ,以脾内移植GM CSF基因修饰的胎肝细胞 (FLC GM)与低剂量IL 2、5 Fu腹腔注射作为基因治疗与化学免疫治疗联合应用方案。