This snide focuses on the pathogenesis of chronic wound and introduces progress in various hinds of treatment, such as shin substitute, growth factors, negative pressure treatment, etc.

• 本文着重讨论了难愈创面的发生机制，并介绍了各种治疗手段如皮肤替代物、生长因子、创面负压治疗技术等的应用进展。