This article reviews the research progress of BSE with epidemiology, aetiology and pathology, discusses the biological property, pathogenic mechanism and replicating model in detail.

• 本文从流行病学、病原学、病理学等方面论述了疯牛病的研究进展情况 ,详细讨论了朊病毒的生物学特性、致病机理和增殖模式