This article is using phage display technology constuncted a naive library of phage-display human Fab library. Obtained the completely humanized Fab antibody against idiotypic antibody of schistosoma japonicum from large naive phage-display library.

• 本文应用噬菌体抗体库技术，构建大容量天然人源Fab抗体库，从中富集、筛选全人源日本血吸虫抗独特型抗体并进行初步鉴定，为研制可用于人体血吸虫病免疫预防的抗独特型抗体疫苗奠定基础。