Thiopheneacetic acid was synthesized from thiophene by chloromethylation, cyanidation togive 2-thiopheneacetonitrile and followed by hydrolysis with an overall yield of 53%.

• 噻吩经氯甲基化、氰化反应得到2-噻吩乙腈,再经水解得到2-噻吩乙酸,总收率53%25。