These increases, with corresponding decreases in receptor actiation, were minor for metoprolol and bisoprolol, and the effects did not did not differ between receptor ariants.

• 上述比率的增加伴随相应的受体活性下降，在美托洛尔和比索洛尔的作用过程中是很小的，而且抑制效应并未因受体变异而发生改变。