These findings suggest that K562 cell line has a capability of inducing acquired resistance to VER,which may be associated with overexpression of PgP,and then leading to reduction of intracellular accumulation of VER in K562/VER cell subline.

• 说明K562细胞系能产生对VER的获得性耐药性，其耐药机制可能与PgP表达过量，并由此导致细胞内VER聚集下降等因素有关。