Therefore HbA_1c as an index for diabetic long-term control should be used with caution in patients with serum creatinine level above 2.Smg/dl.

• 严重的慢性肾功能衰竭者；出现 GHb 随血清肌酐值的升高而呈现有意义的增加；放血清肌酐值在2.；5毫克/分升以上时；对 HbA_1 结果的判断应慎重。