The two regimens of CPT-11 combined with 5-Fu/FA had higher response rate and stable rate in treatment of advanced colorectal cancer. The main DLT is delayed diarrhea and neutropenia.

• CPT-11联合5-Fu/FA两种方案治疗晚期结直肠癌有效率高,毒副反应可以耐受,可作为晚期结直肠癌的一线或二线化疗方案。