The termination of protein synthesis in bacteria requires two codon-specific polypeptide release factors, RF-1 and RF-2. A third factor, RF-3, which accelerate the dissociation of RF1 and RF2 from ribosomes after hydrolysis of peptidyl-tRNA.

• 细菌中蛋白质合成的终止需要两类肽链释放因子,第一类释放因子RF1/RF2和第二类释放因子RF3。