The safety and efficacy of antibiotics with a narrow treatment index and higher toxicity can be enhenced by practicing therapeutic drug monitoring(TDM) and individualized administration.

• 实行治疗药物监测 (therapeuticdrugmonitoring ,TDM )进行给药方案个体化 ,可使治疗指数小、安全范围窄、毒性反应较大的抗菌药物的使用更加安全、有效。