The safe alternative antiplatelet agent for long administration should be used if aspirin resistance appears, prediction of AR and individualization of antiplatelet therapy would be an emerging direction of antiplatelet therapy.

• ASA用于抗血小板治疗及预防动脉硬化事件的脑血管病患者,若有AR存在,应及时换用其它安全有效的抗血小板制剂,因阿司匹林需要长期应用,今后预测AR及抗血小板治疗个体化,将是未来抗血小板治疗的研究方向。