The results suggest that ICAM-1 K469E polymorphism is significantly associated with susceptibility of stroke,E allele and EE homozygote may be risk factors for ischemic stoke.

• ICAM-1基因K469E多态性与缺血性脑卒中发生的易感性有关,E等位基因可能是脑卒中发生的遗传易感标记,纯合突变EE基因型可能是脑卒中的危险因素。