The results showed that 27%(23/85) PZA-resistant isolates had pncA mutations which altered the primary amino acid sequence of pyrazinamidase.

• PZA耐药株有27%25(23/85)发生了pncA基因突变,从而导致吡嗪酰胺酶基本氨基酸序列的改变,突变分布在pncA基因开读框架17-546位的核苷酸。