The purity of Alendronate sodium was 99.8% determined by HPLC.The method presented here has the advantages of mild condition, simple operation, easy isolation, high yield and environmental benignity.

• 结果和结论所得总收率为50%25，此工艺反应条件温和、原料易得、操作简便、产率高、环境友好，产品纯度为99.；8%25。