The preparation and release of compound captopril(1)and hydrochlorothiazide(2)sustained-releasedouble layer tablets (DLT)with hydrophilic gel or mixed matrix were studied.

• 研制了复方卡托普利(1)和氢氯噻嗪(2)缓释双层片,分别考察凝胶骨架与混合骨架双层片的释放度影响因素。