The positive frequencies of RF, APF, AKA and anti-CCP were higher in AFA-positive than in negative ones. AFA was significantly correlated to APF, anti-CCP, AKA while no obvious correlation was found between AFA and RF(P=0.049,near to 0.05).

• RF、APF、AKA 及抗CCP 抗体在AFA 阳性组的阳性率大于阴性组；AFA 与其它自身抗体尤其抗CCP 、APF、AKA 显著相关；与RF 相关性最差P=0.；049。