The molecular weight of each component of modified insulin with LA, DHC, LOA and OA was accurately identified by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS).

• 利用基质辅助激光解吸电离飞行时间质谱(MALDI-TOF-MS)分别确定了LA、DHC、OA和LOA修饰胰岛素粗产物的组分及分子量,每种修饰粗产物实测的各组分的分子量与对应的修饰物理论值完全吻合。