The mice of training group were trained with 17 cm voluntary running wheel for 10 minutes at day 1, and increased by 10 minutes every day until 1 hour a day, for 90 days, training from Monday to Saturday.

• 运动组:将小鼠放进直径为17cm的带轴承转笼,让其主动跑笼,第1天跑10min,以后每天增加10min,直至1h/d,共训练90d,每周一到六训练,周日休息;